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KMID : 0359920080270020248
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Korean Journal of Nephrology
2008 Volume.27 No. 2 p.248 ~ p.250
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Acute Renal Failure Complicated by Valaciclovir in a Patient with IgA Nephropathy
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Kim Jung-Sun
Kim Hye-Won
Lee Jae-Won
Choi Hye-Min
Park Sang-Weon
Lee Young-Mo
Lee Ji-Eun
Kwon Young-Joo
Pyo Heui-Jung
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Abstract
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Valaciclovir is L-valyl ester of acyclovir which has the antiviral effect against herpes zoster virus and Cytomegalovirus. Its adverse effects were reported as nephrotoxicity and neurotoxicity. Although the mechanism of nephrotoxicity of valaciclovir is indeterminate, several hypotheses such as obstructive uropathy and interstitial nephritis have been suggested.
We experienced a 54-year-old female patient with IgA nephropathy who developed acute renal failure after taking valaciclovir. She did not develop either central neuropathy or respiratory muscle weakness. The serum creatinine was normalized after 6 days by withdrawal of valaciclovir and hydration. When we use valaciclovir in the elderly or patients with preexisting renal disease, we should monitor the renal function carefully.
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KEYWORD
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Valaciclovir, , Kidney failure, Acute
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